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KMID : 0369819900200010029
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Jorunal of Korean Pharmaceutical Sciences
1990 Volume.20 No. 1 p.29 ~ p.33
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Development of Controlled Release Oral Drug Delivery System by Membrane - Coating Method - Ⅱ Correlation Between Acetaminophen Concentrations in Plasma and Saliva Samples of Man
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심창구/Shim CK
김미애/이민화/김신근/Kim MA/Lee MH/Kim SK
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Abstract
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Plasma and saliva concentrations of acetaminophen (AAP) were determined at various time points by HPLC after oral administration of AAP tablets (AAP 500 mg) to four healthy male Korean subjects. Saliva concentrations (S) of AAP were significantly correlated with plasma AAP concentrations (P). The S/P ratio of AAP was calculated to be 1.05 (r =0.944, p<10?6) for all the data points from the subjects. It showed a little intersubject variation and ranged from 0.89 to 1.46 in each subject. Bioavailability parameters such as AUC, Cmax and Tmax which are usually obtained from the plasma concentration data will be predictable approximately by saliva concentration data. Saliva seems to be very convinient and useful samples for the preliminary studies of bioavailability and bioequivalence of AAP preparations, since it can be collected frequently without any painful venipuncture to the subjects, that is inevitable in plasma sampling. Evaluation of the bioavailability of a preparation by saliva samples will reduce the cost, time and safety risk greatly in developing a new drug delivery system for AAP.
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